Human CD4 Lymphocytes Specifically Recognize a Peptide Representing the Fusion Region of the Hybrid Protein pml/RARa Present in Acute Promyelocytic Leukemia Cells
نویسندگان
چکیده
Fusion proteins present in leukemic cells frequently contain a new amino acid at the fusion point. We tested whether a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RARa, which is selectively expressed by acute promyelocytic leukemia (APL) cells, can be recognized by human T lymphocytes in vitro. CD4+ lymphocytes, at both polyclonal and clonal level, recognized peptide BCRI /25 in an HLA-DR-restricted fashion on presentation by autologous antigen-presenting cell (APC) or by APC expressing the HLA-DR1 1 restricting molecule. Control peptides corresponding to the normal pml and RARa proteins
منابع مشابه
Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells.
Fusion proteins present in leukemic cells frequently contain a new amino acid at the fusion point. We tested whether a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells, can be recognized by human T lymphocytes in vitro. CD4+ lymphocytes, at both polyclonal and clonal level, recognize...
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